文章基本信息

标题：Influence of immune activation and inflammatory response on cardiovascular risk associated with the human immunodeficiency virus
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作者：Luis M Beltrán ; Alfonso Rubio-Navarro ; Juan Manuel Amaro-Villalobos 等
期刊名称：Vascular Health and Risk Management
印刷版ISSN：1176-6344
电子版ISSN：1178-2048
出版年度：2015
卷号：11
页码：35-48
DOI：10.2147/VHRM.S65885
出版社：Dove Medical Press Ltd
摘要：Patients infected with the human immunodeficiency virus (HIV) have an increased cardiovascular risk. Although initially this increased risk was attributed to metabolic alterations associated with antiretroviral treatment, in recent years, the attention has been focused on the HIV disease itself. Inflammation, immune system activation, and endothelial dysfunction facilitated by HIV infection have been identified as key factors in the development and progression of atherosclerosis. In this review, we describe the epidemiology and pathogenesis of cardiovascular disease in patients with HIV infection and summarize the latest knowledge on the relationship between traditional and novel inflammatory, immune activation, and endothelial dysfunction biomarkers on the cardiovascular risk associated with HIV infection.
关键词：HIV; cardiovascular disease; immune activation; inflammation; antiretroviral therapy