文章基本信息

标题：Challenges for management of post kala-azar dermal leishmaniasis and future directions
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作者：Dinesh Mondal ; Shinjiro Hamano ; Md Golam Hasnain 等
期刊名称：Research and Reports in Tropical Medicine
印刷版ISSN：1179-7282
电子版ISSN：1179-7282
出版年度：2014
卷号：5
页码：105-111
DOI：10.2147/RRTM.S35707
出版社：Dove Medical Press Ltd
摘要：Post kala-azar dermal leishmaniasis (PKDL) is a skin complication resulting from infection with Leishmania donovani (LD) parasite. It mostly affects individuals who have previously suffered from visceral leishmaniasis (VL) caused by LD. In some cases, PKDL develops among people infected with LD, but do not show any symptoms of VL. Clinical presentation includes hypopigmented macules/papules/nodules or polymorphic lesions (combination of two or more lesions). Except for skin lesions, PKDL patients are generally healthy and usually do not seek medical care. These patients play an important role in interepidemic transmission of the infection and subsequent VL outbreak. Therefore, proper diagnosis and treatment of PKDL patients is important for the control of VL in endemic countries, especially in the Indian subcontinent where VL is anthroponotic. Here, we report the challenges in the estimation of PKDL burden, its diagnosis, and treatment, and suggest possible solutions based on recent literature, reports, published manuals, and web-based information.
关键词：post kala-azar dermal leishmaniasis; Bangladesh; challenge; treatment; diagnosis; prevention