文章基本信息

标题：Simultaneous growth of two cancer cell lines demonstrates variability in growth rates
本地全文：下载
作者：Agnes Hamon ; Marie Tosolini ; Bernard Ycart 等
期刊名称：Open Access Medical Statistics
印刷版ISSN：2230-3251
电子版ISSN：2230-3251
出版年度：2014
卷号：4
页码：29-37
DOI：10.2147/OAMS.S68945
出版社：Dove Medical Press Ltd
摘要：Cancer cells cocultured in vitro show unexpected differential growth rates that classical exponential growth models cannot account for. Two noninteracting cell lines were grown in the same culture, and counts of each species were recorded at periodic intervals. The relative growth of population ratios was found to depend on the initial proportion, in contrast with the traditional exponential growth model. A proposed explanation is the variability of growth rates for clones inside the same cell line. This leads to a log-quadratic growth model that provides both a theoretical explanation for the phenomenon that was observed, and a better fit for our growth data.
关键词：cancer cells; growth; log-linear model