文章基本信息

标题：Solid-phase microextraction for bioconcentration studies according to OECD TG 305
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作者：Rolf-Alexander Düring ; Leonard Böhm ; Christian Schlechtriem 等
期刊名称：Environmental Sciences Europe
印刷版ISSN：2190-4715
出版年度：2012
卷号：24
期号：1
页码：4
DOI：10.1186/2190-4715-24-4
语种：English
出版社：BioMed Central
摘要：An important aim of the European Community Regulation on chemicals and their safe use is the identification of (very) persistent, (very) bioaccumulative, and toxic substances. In other regulatory chemical safety assessments (pharmaceuticals, biocides, pesticides), the identification of such (very) persistent, (very) bioaccumulative, and toxic substances is of increasing importance. Solid-phase microextraction is especially capable of extracting total water concentrations as well as the freely dissolved fraction of analytes in the water phase, which is available for bioconcentration in fish. However, although already well established in environmental analyses to determine and quantify analytes mainly in aqueous matrices, solid-phase microextraction is still a rather unusual method in regulatory ecotoxicological research. Here, the potential benefits and drawbacks of solid-phase microextraction are discussed as an analytical routine approach for aquatic bioconcentration studies according to OECD TG 305, with a special focus on the testing of hydrophobic organic compounds characterized by log KOW > 5.
关键词：particulate and dissolved organic matter ; bioconcentration factor ; bioavailability ; hydrophobic organic chemicals ; registration and authorization of chemicals