文章基本信息

标题：Tox-Box: securing drops of life - an enhanced health-related approach for risk assessment of drinking water in Germany
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作者：Tamara Grummt ; Jochen Kuckelkorn ; Arnold Bahlmann 等
期刊名称：Environmental Sciences Europe
印刷版ISSN：2190-4715
出版年度：2013
卷号：25
期号：1
页码：27
DOI：10.1186/2190-4715-25-27
语种：English
出版社：BioMed Central
摘要：This article introduces ‘Tox-Box’, a joint research project designed to develop a holistic approach towards a harmonized testing strategy for exposure- and hazard-based risk management of anthropogenic trace substances in drinking water to secure a long-term drinking water supply. The main task of the Tox-Box consortium is to enhance the existing health-related indicator value concept (German: GOW-Konzept - Gesundheitlicher Orientierungswert) through development and prioritization of additional end point-related testing strategies for genotoxicity, neurotoxicity, germ cell damage, and endocrine effects. In this context, substance-specific modes of action will be identified and characterized. Toxicological data collected by the 12 Tox-Box subprojects will be evaluated and weighted to structure a hierarchical testing strategy for an improved risk assessment. A technical guidance document for exposure and hazard-based risk management of anthropogenic trace substances in drinking water will eventually be prepared.
关键词：Neurotoxicity ; Zebra Fish ; Trace Substance ; Federal Environment Agency ; German Federal Environment Agency