文章基本信息

标题：The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods
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作者：Per Hove Thomsen ; Nor C Torp ; Kitty Dahl 等
期刊名称：Child and Adolescent Psychiatry and Mental Health
印刷版ISSN：1753-2000
电子版ISSN：1753-2000
出版年度：2013
卷号：7
期号：1
页码：41
DOI：10.1186/1753-2000-7-41
语种：English
出版社：BioMed Central
摘要：This paper describes and discusses the methodology of the Nordic long-term OCD-treatment study (NordLOTS). The purpose of this effectiveness study was to study treatment outcome of CBT, to identify CBT non- or partial responders and to investigate whether an increased number of CBT-sessions or sertraline treatment gives the best outcome; to identify treatment refractory patients and to investigate the outcome of aripiprazole augmentation; to study the outcome over a three year period for each responder including the risk of relapse, and finally to study predictors, moderators and mediators of treatment response. Step 1 was an open and uncontrolled clinical trial with CBT, step 2 was a controlled, randomised non-blinded study of CBT non-responders from step 1. Patients were randomized to receive either sertraline plus CBT-support or continued and modified CBT. In step 3 patients who did not respond to either CBT or sertraline were treated with aripiprazole augmentation to sertraline. This multicenter trial covering three Scandinavian countries is going to be the largest CBT-study for paediatric OCD to date. It is not funded by industry and tries in the short and long-term to answer the question whether further CBT or SSRI is better in CBT non-responders.
关键词：Study design ; Multisite study ; Child and adolescents ; Obsessive-compulsive disorder ; Cognitive behavioural therapy ; Stepped care design ; Treatment outcome