文章基本信息

标题：Outdoor particulate matter and childhood asthma admissions in Athens, Greece: a time-series study
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作者：Panagiotis T Nastos ; Athanasios G Paliatsos ; Michael B Anthracopoulos 等
期刊名称：Environmental Health - a Global Access Science Source
印刷版ISSN：1476-069X
电子版ISSN：1476-069X
出版年度：2010
卷号：9
期号：1
页码：45
DOI：10.1186/1476-069X-9-45
语种：English
出版社：BioMed Central
摘要：Particulate matter with diameter less than 10 micrometers (PM10) that originates from anthropogenic activities and natural sources may settle in the bronchi and cause adverse effects possibly via oxidative stress in susceptible individuals, such as asthmatic children. This study aimed to investigate the effect of outdoor PM10 concentrations on childhood asthma admissions (CAA) in Athens, Greece. Daily counts of CAA from the three Children's Hospitals within the greater Athens' area were obtained from the hospital records during a four-year period (2001-2004, n = 3602 children). Mean daily PM10 concentrations recorded by the air pollution-monitoring network of the greater Athens area were also collected. The relationship between CAA and PM10 concentrations was investigated using the Generalized Linear Models with Poisson distribution and logistic analysis. There was a statistically significant (95% CL) relationship between CAA and mean daily PM10 concentrations on the day of exposure (+3.8% for 10 μg/m3 increase in PM10 concentrations), while a 1-day lag (+3.4% for 10 μg/m3 increase in PM10 concentrations) and a 4-day lag (+4.3% for 10 μg/m3 increase in PM10 concentrations) were observed for older asthmatic children (5-14 year-old). High mean daily PM10 concentration (the highest 10%; >65.69 μg/m3) doubled the risk of asthma exacerbations even in younger asthmatic children (0-4 year-old). Our results provide evidence of the adverse effect of PM10 on the rates of paediatric asthma exacerbations and hospital admissions. A four-day lag effect between PM10 peak exposure and asthma admissions was also observed in the older age group.
关键词：Asthma ; Asthma Exacerbation ; PM10 Concentration ; Atopic Sensitisation ; Great Athens Area