文章基本信息

标题：Mode of action of fibrous amphiboles: the case of Biancavilla (Sicily, Italy).
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作者：Giulia Ballan ; Antonella Del Brocco ; Stefano Loizzo 等
期刊名称：Annali dell'Istituto Superiore di Sanita
印刷版ISSN：0021-2571
出版年度：2014
卷号：50
期号：2
页码：133-138
DOI：10.4415/ANN_14_02_05
出版社：Editrice Kurtis Srl
摘要：Background. The inhalation of fibrous amphiboles can result in pulmonary fibrosis, lung cancer and mesothelioma. Although these fibres have the same disease-causing potential, their different morphologies and chemical composition can determine different biological activities. An unusual cluster of mesothelioma was evidenced in Biancavilla (Sicily) where no inhabitant had been significantly exposed to asbestos. Objective. We herein discuss the mechanism of action of amphiboles, focusing on the fibres identified in the study area. Results. Human lung carcinoma cells have been exposed to two different materials: prismatic fluoro-edenite and fibres with fluoro-edenitic composition. Only in the second case, they exhibit features typical of transformed cells, such as multinucleation, pro- survival activity and pro-inflammatory cytokine release. Accordingly, in vivo studies demonstrated that the fibrous sample only could induce a mesotheliomatogenic effect. Conclusions. Fibres with fluoro-edenitic composition behave similarly to the asbestos crocidolite, whose connection with inflammation and lung cancer is well established.
关键词：fibrous amphiboles ; . asbestos ; . fluoro-edenite ; . Biancavilla ; . mesothelioma