文章基本信息

标题：Electrical Signal Guided Ibuprofen Release from Electrodeposited Chitosan Hydrogel
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作者：Youyu Liu ; Kun Yan ; Guoxia Jiang 等
期刊名称：International Journal of Polymer Science
印刷版ISSN：1687-9422
电子版ISSN：1687-9430
出版年度：2014
卷号：2014
DOI：10.1155/2014/736898
出版社：Hindawi Publishing Corporation
摘要：Electrical signal guided drug release from conductive surface provides a simple and straightforward way for advanced drug delivery. In this study, we investigated the ibuprofen release from electrodeposited chitosan hydrogel by applying electrical signals. Specifically, chitosan hydrogel was electrodeposited on titanium plate and used as a matrix for ibuprofen load and release. The release of ibuprofen from the chitosan hydrogel on titanium plate was pH sensitive. By applying a positive or negative electrical potential, the release rate of ibuprofen from the electrodeposited chitosan can be facilely controlled. Thus, coupling chitosan electrodeposition and electrical signal control spurs new possibilities for biopolymeric coating and drug elution on conductive implants.