文章基本信息

标题：Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants
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作者：Charles Maisonneuve ; Sylvie Bertholet ; Dana J. Philpott 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2014
卷号：111
期号：34
页码：12294-12299
DOI：10.1073/pnas.1400478111
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Innate immunity confers an immediate nonspecific mechanism of microbial recognition through germ line-encoded pattern recognition receptors (PRRs). Of these, Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) have shaped our current understanding of innate regulation of adaptive immunity. It is now recognized that PRRs are paramount in instructing an appropriate adaptive immune response. Their ligands have been the focus of adjuvant research with the goal of generating modern vaccine combinations tailored to specific pathogens. In this review we will highlight the recent findings in the field of adjuvant research with a particular focus on the potential of TLR and NLR ligands as adjuvants and their influence on adaptive immune responses.
关键词：NOD1 ; NOD2 ; NLRP3 ; TLR4 alum