文章基本信息

标题：UTILITY OF A COMBINATION ANTIBIOGRAM FOR TREATING PSEUDOMONAS AERUGINOSA
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作者：Lindsay Thurman ; Nathan Fewel ; Michael Rose 等
期刊名称：American Journal of Infectious Diseases
印刷版ISSN：1553-6203
出版年度：2014
卷号：10
期号：2
页码：88-94
DOI：10.3844/ajidsp.2014.88.94
语种：English
出版社：Science Publications
摘要：Empiric combination antibiotic therapy is often used to treat severe P. aeruginosa infections. Combination antibiograms have been employed to assist clinicians in selecting the most effective two-drug antibiotic regimens. The objectives of this study were to develop a combination antibiogram in order to compare beta-lactam monotherapy versus dual-therapy with a fluoroquinolone or aminoglycoside, identify optimal combination regimens, describe the differences between combination therapies with an aminoglycoside versus a fluoroquinolone and to evaluate susceptibility rates based on the source of infection and Intensive Care Unit (ICU) or non-ICU location. A retrospective observational study at a Veterans Affairs (VA) hospital in the Southwestern region of the U.S. was conducted. P. aeruginosa isolates were collected between January 2008 and February 2012 in hospitalized veterans. A total of 374 isolates were included, of which 61 (16%) were obtained from the ICU. Susceptibility rates for monotherapy with a beta-lactam ranged from 83.7 to 90.6%. Collectively, all P. aeruginosa isolates benefited in coverage with the addition of a fluoroquinolone or an aminoglycoside to one of the beta-lactams considered for monotherapy (p P. aeruginosa . Choosing the ideal antibiotic regimen ultimately deals with many factors and results of this combination antibiogram are only specific to this institution.
关键词：Combination Antibiogram; Pseudomonas aeruginosa; Combination Therapy; Monotherapy