文章基本信息

标题：A novel statistical analysis and interpretation of flow cytometry data
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作者：H.T. Banks ; D.F. Kapraun ; W. Clayton Thompson 等
期刊名称：Journal of Biological Dynamics
印刷版ISSN：1751-3758
电子版ISSN：1751-3766
出版年度：2013
卷号：7
期号：1
页码：96-132
DOI：10.1080/17513758.2013.812753
出版社：Taylor & Francis
摘要：A recently developed class of models incorporating the cyton model of population generation structure into a conservation-based model of intracellular label dynamics is reviewed. Statistical aspects of the data collection process are quantified and incorporated into a parameter estimation scheme. This scheme is then applied to experimental data for PHA-stimulated CD4+T and CD8+T cells collected from two healthy donors. This novel mathematical and statistical framework is shown to form the basis for accurate, meaningful analysis of cellular behaviour for a population of cells labelled with the dye carboxyfluorescein succinimidyl ester and stimulated to divide.
关键词：immunology; flow cytometry; cyton models; mathematical and statistical models; label dynamics; parameter estimation; cellular models