文章基本信息

标题：Treatment-resistant depression: A systematic review of systematic reviews
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作者：Alia Inés Pérez-Wehbe ; Lilisbeth Perestelo-Pérez ; Juan Manuel Bethencourt-Pérez 等
期刊名称：International Journal of Clinical and Health Psychology
电子版ISSN：1697-2600
出版年度：2014
卷号：14
期号：2
页码：1-9
DOI：10.1016/S1697-2600(14)70048-1
出版社：Elsevier B.V.
摘要：The objective of this research study was to assess pharmacological, somatic and/or psychological treatments in adults with a diagnosis of major depressive disorder who have not responded to at least one course of antidepressant medication. We conducted a systematic review to identify systematic scientific reviews and meta-analyses on treatment-resistant depression (TRD) published until February 2012. Of the sixty studies selected, sixteen met the inclusion criteria and were therefore included in the review. We considered eight main themes, including the definition of TRD, long-term results, and different treatment strategies, including so-called somatic therapies. Based on the review, the definition of TRD should be standardized in order to achieve a shared conceptualization of this disorder. This would allow a better understanding among clinicians and researchers in the field, promoting a homogeneous research methodology and thus leading to more reliable and comparable results. This essential conceptual clarification would also have a positive impact on patients with TRD, their families, and social and health systems.
关键词：Treatment-resistant depression ; Refractory depression ; Treatment ; Systematic review ; Theoretical study