文章基本信息

标题：Statins in heart failure: do we need another trial?
本地全文：下载
作者：Kwadwo Osei Bonsu ; Amudha Kadirvelu ; Daniel Diamond Reidpath 等
期刊名称：Vascular Health and Risk Management
印刷版ISSN：1176-6344
电子版ISSN：1178-2048
出版年度：2013
卷号：9
页码：303-319
DOI：10.2147/VHRM.S44499
出版社：Dove Medical Press Ltd
摘要：Statins lower serum cholesterol and are employed for primary and secondary prevention of cardiovascular events. Clinical evidence from observational studies, retrospective data, and post hoc analyses of data from large statin trials in various cardiovascular conditions, as well as small scale randomized trials, suggest survival and other outcome benefits for heart failure. Two recent large randomized controlled trials, however, appear to suggest statins do not have beneficial effects in heart failure. In addition to lowering cholesterol, statins are believed to have many pleotropic effects which could possibly influence the pathophysiology of heart failure. Following the two large trials, evidence from recent studies appears to support the use of statins in heart failure. This review discusses the role of statins in the pathophysiology of heart failure, current evidence for statin use in heart failure, and suggests directions for future research.
关键词：statins; treatment; heart failure; comorbidity; mortality