文章基本信息

标题：Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress
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作者：Jacob George ; Allan D Struthers
期刊名称：Vascular Health and Risk Management
印刷版ISSN：1176-6344
电子版ISSN：1178-2048
出版年度：2009
卷号：5
页码：265-272
DOI：10.2147/VHRM.S4265
出版社：Dove Medical Press Ltd
摘要：Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor, has been in clinical use for over 40 years in the treatment of chronic gout. Allopurinol has also been shown to improve endothelial dysfunction, reduce oxidative stress burden and improve myocardial efficiency by reducing oxygen consumption in smaller mechanistic studies involving various cohorts at risk of cardiovascular events. This article aims to explain the role of xanthine oxidase in vascular oxidative stress and to explore the mechanisms by which allopurinol is thought to improve vascular and myocardial indices.
关键词：allopurinol; vascular oxidative stress; vascular endothelial dysfunction