文章基本信息

标题：Targeting mulitple dyslipidemias with fixed combinations – focus on extended release niacin and simvastatin
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作者：Anbu Pandian ; Anjali Arora ; Laurence S Sperling 等
期刊名称：Vascular Health and Risk Management
印刷版ISSN：1176-6344
电子版ISSN：1178-2048
出版年度：2008
卷号：4
期号：5
页码：1001-1009
DOI：10.2147/VHRM.S3460
出版社：Dove Medical Press Ltd
摘要：Dyslipidemia is a major risk factor in the initiation and progression of cardiovascular diseases such as atherosclerosis. Several pharmacological agents have been developed over the past 50 years which target various lipid components such as low density lipoprotein (LDL) cholesterol, triglyceride, and high density lipoprotein (HDL) cholesterol. Similar to other risk factors such as hypertension and diabetes mellitus, the management of dyslipidemia can be complicated and may require combination therapy for effective treatment. This review discusses the biochemical mechanisms of action and clinical uses for simvastatin (the most widely available and commercially prescribed statin) and niacin, and the combination of these agents in the management and treatment of dyslipidemia.
关键词：dyslipidemia; HDL cholesterol; triglyceride; statin; niacin