文章基本信息

标题：Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers
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作者：Camelia R Ban ; Stephen M Twigg
期刊名称：Vascular Health and Risk Management
印刷版ISSN：1176-6344
电子版ISSN：1178-2048
出版年度：2008
卷号：4
期号：3
页码：575-596
DOI：10.2147/VHRM.S1991
出版社：Dove Medical Press Ltd
摘要：Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often with associated insulin resistance. Over time, especially in genetically susceptible individuals, such chronic hyperglycemia can cause tissue injury. One pathological response to tissue injury is the development of fibrosis, which involves predominant extracellular matrix (ECM) accumulation. The main factors that regulate ECM in diabetes are thought to be pro-sclerotic cytokines and protease/anti-protease systems. This review will examine the key markers and regulators of tissue fibrosis in diabetes and whether their levels in biological fluids may have clinical utility.
关键词：diabetic complications; extracellular matrix; markers