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标题：Trypanosoma cruzi in dogs: electrocardiographic and echocardiographic evaluation, in Malinalco, State of Mexico
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作者：Sandra Díaz González-Vieyra ; Ninfa Ramírez-Durán ; Ángel H Sandoval-Trujillo 等
期刊名称：Research and Reports in Tropical Medicine
印刷版ISSN：1179-7282
电子版ISSN：1179-7282
出版年度：2011
卷号：2
页码：155-161
DOI：10.2147/RRTM.S21683
出版社：Dove Medical Press Ltd
摘要：Chagas disease caused by Trypanosoma cruzi is an important public health problem in Latin America. Dogs are considered a risk factor for human Chagas disease, a sentinel for T. cruzi infection in endemic regions and an animal model to study pathological aspects of the disease. The potential use of dogs as indicators of human cardiac pathogenicity of local T. cruzi strains has been studied insufficiently. We studied electrocardiographic (EKG) and echocardiographic (ECG) alteration frequencies observed in an open population of dogs in Malinalco, Mexico, and determined if such frequencies were statistically associated with T. cruzi infection in dogs. Animals (n = 139) were clinically examined and owners were asked to answer a questionnaire about dogs’ living conditions. Two commercial serological tests (IHA, ELISA) were conducted to detect anti- T. cruzi serum antibodies. Significant differences between seropositive and seronegative animals in cardiomyopathic frequencies were detected through EKG and ECG ( P < 0.05). Thirty dogs (21.58%) were serologically positive to anti- T. cruzi antibodies (to ELISA and IHA assays), of which nine (30%) had EKG and/or ECG alterations. From the remaining 104 (78.42%) seronegative animals, five (4.5%) had EKG and/or ECG abnormalities. Our data support the hypothesis that most EKG and ECG alterations found in dogs from Malinalco could be associated with T. cruzi infection. Considering the dog as a sentinel and as an animal model for Chagas disease in humans, our findings suggest that the T. cruzi strains circulating in Malinalco have the potential to produce cardiomyopathies in infected humans.
关键词：chagas disease; Trypanosoma cruzi ; cardiomyopathy; electrocardiography; echocardiography; Malinalco; México