文章基本信息

标题：Body mass index and the risk of prostate cancer
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作者：Daniel Lee McGee ; Carlos J Crespo
期刊名称：Open Access Medical Statistics
印刷版ISSN：2230-3251
电子版ISSN：2230-3251
出版年度：2012
卷号：2
页码：53-60
DOI：10.2147/OAMS.S34645
出版社：Dove Medical Press Ltd
摘要：Background: This article presents cohort studies that use data from the National Health Information Survey from 1986 to 1994 and compares the effectiveness of Cox proportional hazards models that assume a linear relationship between body mass index (BMI) and the risk of prostate cancer with models that assume a J-shaped relationship. Methods and results: Our study found that for black males over 40 years of age, neither a linear nor a J-shaped relationship yielded a statistically significant model. With white males over 40 years, assuming a linear relationship did not yield a statistically significant model ( P = 0.582). When we assume a J-shaped relationship, the optimal change point where the risk of prostate cancer death is minimized occurs when the BMI is 25.5. Among white males over 40 years with BMI < 25.5, an inverse relationship was found ( P = 0.009). Among white males over 40 years with BMI > 25.5, a direct relationship was found ( P = 0.017). Conclusion: With this data set, we found that for white males over 40 years, Cox proportional hazards models that assume a J-shaped relationship between BMI and prostate cancer death provide a much better fit than models assuming a linear relationship.
关键词：body mass index; prostate cancer; J-shaped curve; Cox proportional hazards model; Kaplan-Meier model; National Health Information Survey