文章基本信息

标题：Nanocarrier-based immunotherapy in cancer management and research
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作者：Video abstract presented by Manu Smriti Singh Views: Manu Smriti Singh ; Sangeeta Bhaskar
期刊名称：ImmunoTargets and Therapy
电子版ISSN：2253-1556
出版年度：2014
卷号：3
页码：121-134
DOI：10.2147/ITT.S62471
出版社：Dove Medical Press Ltd
摘要：Research in cancer immunotherapy has gained momentum in the last two decades, with many studies and clinical trials showing positive therapeutic outcomes. Immunotherapy can elicit not only a strong anticancer immune response which could even control metastases, but could also induce immunological memory, resulting in long-lasting protection in the prophylactic setting and protection against possible recurrence. Nanocarriers offer an attractive means for delivery of a multitude of therapeutic immunomodulators which are readily taken up by immune cells and can initiate a particular arm of an immunostimulatory cascade leading to tumor cell killing. This review focuses on recent advances in nanocarrier-mediated immunotherapy for the treatment of cancer. Both in vitro and in vivo studies as well as clinical progress are discussed in various sections. Description of the specific role of nanoparticle technology in immunotherapy highlights the way particles can be tailor-made in terms of size, structure, payload, and surface properties for active targeting to antigen-presenting cells and/or enhanced accumulation in the solid tumor.
关键词：cancer; immunotherapy; nanocarriers