文章基本信息

标题：Fetal valproate syndrome in a 14-month-old child: A case report
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作者：A Abbas ; U Firdaus
期刊名称：South African Journal of Child Health
印刷版ISSN：1994-3032
电子版ISSN：1999-7671
出版年度：2013
卷号：7
期号：2
页码：74-76
语种：English
出版社：African Journals Online
摘要：Anti-epileptic drugs administered during pregnancy can cause structural defects in the growing fetus and result in adverse neurodevelopmental outcome later in life. Fetal valproate syndrome (FVS) results from teratogenic effects of valproic acid exposure in the prenatal period. It is characterised by a distinctive dysmorphic facies and a cluster of minor and major anomalies, as well as developmental and behavioural abnormalities. We describe a 14-month-old boy with the typical dysmorphic facies and other congenital abnormalities characteristic of FVS. There was a history of maternal intake of sodium valproate during pregnancy. The mechanism of teratogenicity and methods for prevention are discussed.