文章基本信息

标题：Fetal hemoglobin during infancy and in sickle cell adults
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作者：Dominic Edoh ; Charles Antwi-Bosaiko ; Dominic Amuzu 等
期刊名称：African Health Sciences
印刷版ISSN：1680-6905
电子版ISSN：1729-0503
出版年度：2006
卷号：6
期号：1
页码：51-54
DOI：10.4314/ahs.v6i1.6925
语种：English
出版社：Makerere University Medical School（Uganda)
摘要：Background : Fetal hemoglobin has been implicated in the modulation of sickle cell crisis though it is functional during infancy. Objective : The purpose of this study was to determine the waning time of fetal hemoglobin (HbF) and its persistence in later life. Method: Ninety infants aged 0-12 months, admitted at hospital, were tested for their HbF levels. Adult patients numbering 690 were also examined for their sickle cell status and a sickle positive patient of SS type with HbF had her family members recruited and their sickle cell types determined. Results : The results revealed that HbF was highest (98%) at birth, decreasing at 5% per week till 6 months when it wane off. Ten infants aged 6–12 months had HbF persisting at a level of 10% or more. Adult patients examined showed proportions of their sickle cell types as AS forming 51%, AC 20%, SS 19%, and SC 10%. An SS adult patient with mild sickle cell crisis had an ASF father who had no crisis and a mother and brother with AS each who had severe crisis. Conclusion : These findings suggest that HbF wanes off during infancy but persist in some adults and may modulate crisis in these adults. This has implications in sickle cell management. African Health Sciences Vol. 6(1) 2006: 51-54