文章基本信息

标题：Correlation between the cystathionine-r-lyase (CES) and the severity of peptic ulcer disease
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作者：Xiong Chen ; Ying-Chun Wan ; Tao Guo 等
期刊名称：African Health Sciences
印刷版ISSN：1680-6905
电子版ISSN：1729-0503
出版年度：2014
卷号：14
期号：1
页码：189-194
DOI：10.4314/ahs.v14i1.29
语种：English
出版社：Makerere University Medical School（Uganda)
摘要：Background: The infection of Helicobacter pylori ( H. pylori ) is one of the most important causes of gastric ulcer disease. The role of hydrogen sulfide (H₂S) production in H. pylori-induced gastric ulcer disease. Aim: The expression of cystathionine-γ-lyase (CSE) was determined, and correlated with the severity of gastric ulcer disease. Methods: 108 patients were selected based on the determination of gastric ulcer and the infection of Helicobacter pylori ( H. pylori ), including 36 normal control, 36 patients with H. Pylori-negative gastric ulcer, and 36 patients with H. Pylori -positive gastric ulcer. RT-PCR determination was performed to determine the expression of CSE, NF-κB and IL-8. Results: The expression of CSE, NF-κB and IL-8 was higher in gastric ulcer group than control group (p < 0.05). Compared with the H.pylori -negative gastric ulcer, the expression of CSE, NF-κB and IL-8 was higher than H.pylori -positive gastric ulcer group (p < 0.05). For H.pylori -negative gastric ulcer group, the expression of CSE positively correlated with the expression of NF-κB (r=0.98, p < 0.05) and IL-8 (r=0.95, p 0.05). For H.pylori -positive gastric ulcer group, the expression of CSE also positively correlated with the expression of NF-κB (r=0.99, p < 0.05) and IL-8 (r=0.85, p < 0.05). Conclusion: The expression of CSE was positively correlated with the severity of gastric ulcer.