文章基本信息

标题：Field Trial of a Thermostable Peste des petits ruminants (PPR) Vaccine in a Semi-Arid Zone of Nigeria
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作者：Abdul-Dahiru El-Yuguda ; Saka Saheed Baba ; Abdul Ganiyu Ambali 等
期刊名称：World Journal of Vaccines
印刷版ISSN：2160-5815
电子版ISSN：2160-5823
出版年度：2014
卷号：4
期号：1
页码：1-6
DOI：10.4236/wjv.2014.41001
出版社：Scientific Research Publishing
摘要：The field trial of a candidate thermostable Peste des petits ruminants (PPR) vaccine was carried out in flocks of sheep and goats under the extensive system of management. The immune response of vaccinated animals was determined using the neutralisation test to detect PPR virus specific antibody. Vaccinated animals seroconverted and a four-fold or more rise in antibody titre were observed between pre-vaccination and post-vaccination antibodies. The vaccine elicited significant antibody response in goats through the different routes of administration (intramuscular, intranasal, intraocular, subcutaneous and orally), but was poorly transmitted between the vaccinees and in-contact animals. The sheep responded poorly to the vaccine administered through most of the routes, except for those vaccinated through intramuscular and subcutaneous routes that seroconverted significantly (≥4 fold rise). The vaccine retained a potent titre of 3.1 log10 TCID50 for more than 8 hours after reconstitution in PBS at room temperature. Based on the response of goats to oral vaccination, it is suggested that the vaccine could be administered on the field through the oral routes and has the potential to be adapted to a feed-based administration for wider application to the scattered livestock populations under the extensive system of management.
关键词：Thermostable PPR Vaccine; Sheep; Goats; Virus Neutralisation Test; Nigeria