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标题：Nitric Oxide Scavenger Carboxy-PTIO Impaired Memory of Avoidance Conditioning in Goldfish
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作者：X. Xu ; K. Zmolek
期刊名称：Open Journal of Social Sciences
印刷版ISSN：2327-5952
电子版ISSN：2327-5960
出版年度：2014
卷号：2
期号：5
页码：86-89
DOI：10.4236/jss.2014.25017
出版社：Scientific Research Publishing
摘要：The long-term potentiation (LTP), an activity-induced increase in the efficacy of neurotransmission, has long been conceived to be a physiological correlate of learning and memory. Investigations of synaptic transmission suggest that the postsynaptic N-methyl-D-aspartate (NMDA) receptor is the upstream mediator of LTP, while nitric oxide (NO), a retrograde messenger from postsynaptic neurons to presynaptic neuron, is the downstream mediator of LTP. Our previous studies showed that microinjections of NMDA receptor antagonist D-AP5 to the goldfish telencephalon prior to trainings impaired learning of avoidance conditioning in goldfish. However, microinjections of D-AP5 to the goldfish telencephalon immediately following trainings did not impair memory of avoidance conditioning. Carboxy-PTIO is a NO scavenger that prevents NO from reaching the presynaptic neurons. The present study investigated the effects of microinjections of carboxy-PTIO to the goldfish telencephalon immediately following trainings on avoidance conditioning. The results showed that microinjections of carboxy-PTIO to the goldfish telencephalon immediately following trainings impaired memory of avoidance conditioning.
关键词：Avoidance Conditioning; Memory Consolidation; Nitric oxide; Goldfish