文章基本信息

标题：Feasibility of latent tuberculosis infection diagnosis by interferon-gamma release assay remote from testing facilities
本地全文：下载
作者：James M Trauer ; Krispin M Hajkowicz ; Kevin G Freeman 等
期刊名称：Communicable Diseases Intelligence
印刷版ISSN：1447-4514
电子版ISSN：1445-4866
出版年度：2011
卷号：35
期号：2
页码：168-171
出版社：Government Department of Health and Ageing
摘要：Although the tuberculin skin test (TST) has been the mainstay of the diagnosis of latent tuberculosis infection (LTBI) for many decades, interferon-gamma release assays (IGRAs) are gaining acceptance and are more specific for this diagnosis. The characteristics of one such IGRA, the QuantiFERON®-TB Gold Whole Blood In-Tube, make it feasible for use in a remote setting. This study performed 62 IGRAs with this test on individuals testing positive by TST, in a clinical setting over 3,000 km from the testing laboratory. Of these, 42 patients (68%) recorded negative results, 19 (31%) were positive, with only 1 result (2%) indeterminate. Negative, and therefore discordant in this study, test results were more common in those known to have been previously vaccinated with bacille Calmette-Guérin. These results are consistent with other reports, indicating that this approach to testing is logistically feasible, and has the potential to complement LTBI screening to assist tuberculosis control programs in settings remote from the testing laboratory.
关键词：tuberculin test; tuberculosis;interferon-gamma release assay; rural health;services