文章基本信息

标题：PDGFRβ reverses EphB4 signaling in alveolar rhabdomyosarcoma
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作者：M. Imran Aslam ; Jinu Abraham ; Atiya Mansoor 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2014
卷号：111
期号：17
页码：6383-6388
DOI：10.1073/pnas.1403608111
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Alveolar rhabdomyosarcoma (aRMS) is an aggressive myogenic childhood malignancy, not infrequently presenting as incurable metastatic disease. To identify therapeutic targets, we performed an unbiased tyrosine kinome RNA interference screen in primary cell cultures from a genetically engineered, conditional mouse model of aRMS. We identified ephrin receptor B4 (EphB4) as a target that is widely expressed in human aRMS and that portends a poor clinical outcome in an expression level-dependent manner. We also uncovered cross-talk of this ephrin receptor with another receptor tyrosine kinase, PDGFR{beta
关键词：sarcoma ; pediatric ; muscle