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标题：Annual report on surveillance of adverse events following immunisation in Australia, 2006
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作者：Glenda L Lawrence ; Padmasiri E Aratchige ; Ian Boyd 等
期刊名称：Communicable Diseases Intelligence
印刷版ISSN：1447-4514
电子版ISSN：1445-4866
出版年度：2007
卷号：31
期号：3
页码：269-283
出版社：Government Department of Health and Ageing
摘要：This report summarises Australian passive surveil-lance data for adverse events following immunisa-tion (AEFI) reported to the Adverse Drug Reactions Advisory Committee for 2006, and describes report-ing trends over the seven-year period 2000 to 2006. There were 779 AEFI records for vaccines adminis-tered in 2006. This is an annual AEFI reporting rate of 3.8 per 100,000 population, the lowest since 2002 and a 10% decrease compared with 2005 (869 AEFI records; 4.3 records per 100,000 popu-lation). Dose-based AEFI reporting rates in 2006 were 1.9 per 100,000 doses of influenza vaccine for adults aged ≥18 years, 19.1 per 100,000 doses of pneumococcal polysaccharide vaccine for those aged ≥65 years and 12.5 per 100,000 doses of scheduled vaccines for children aged <7 years. Trend data showed transient increases in report-ing of AEFI following the introduction of DTPa-IPV combination vaccines in November 2005 for chil-dren aged <7 years. The majority of the 779 AEFI records for 2006 described non-serious events while 11% (n=85) described AEFIs defined as serious. There was one report of death temporally associ-ated with receipt of dTpa-IPV and typhoid vaccines in an adult with a history of a chronic medical con-dition. The most frequently reported individual AEFI was injection site reaction in children following a fourth or fifth dose of acellular pertussis-containing vaccine (70 reports per 100,000 doses). The data confirm the low rate of AEFI reported in Australia and demonstrate the ability of the system to detect and investigate signals such as those associated with changes in immunisation programs
关键词：AEFI; adverse events; vaccines; ;surveillance; immunisation; vaccine safety