文章基本信息

标题：Epidemic viral gastroenteritis in Queensland coincides with the emergence of a new norovirus variant
本地全文：下载
作者：Michael J Lyon ; Gang Wei ; Greg A Smith 等
期刊名称：Communicable Diseases Intelligence
印刷版ISSN：1447-4514
电子版ISSN：1445-4866
出版年度：2005
卷号：29
期号：4
页码：370-373
出版社：Government Department of Health and Ageing
摘要：Norovirus infections cause widespread morbidity and have signifi cant economic impact on the com-munity. An increase in outbreaks of norovirus gastroenteritis in hospitals, nursing homes and in the community was observed in Queensland in 2004. Molecular analysis of positive samples indicated the emergence of a single strain of norovirus. A 252 nucleotide sequence from the polymerase region (POL) was compared to sequences of the new variant genotype GII.4 that has caused epidemics in the Northern Hemisphere in 2002 and 2003. Sequence analysis indicated greater than 95 per cent similarity in the POL between the Queensland strain and the Northern Hemisphere 2002/3 GII.4 variant. Phylogenetic analysis revealed that the Queensland strain forms a branch within the GII.4 genotype separate from the 2002 variant from Europe and North America. Although norovirus genotype GII.4 had circulated in Queensland in the past, the 2004 strain was characterised specifi cally by three nucleotides not present in any other sequences held in our database covering the years 2002–June 2004
关键词：norovirus; epidemic; new variant