文章基本信息

标题：Age-related risk of adverse events following yellow fever vaccination in Australia
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作者：Glenda Lawrence ; Margaret Burgess ; Robert Kass 等
期刊名称：Communicable Diseases Intelligence
印刷版ISSN：1447-4514
电子版ISSN：1445-4866
出版年度：2004
卷号：28
期号：2
页码：244-248
出版社：Government Department of Health and Ageing
摘要：Reports of six deaths internationally, including one from Australia, plus other cases of severe systemic adverse events following yellow fever (YF) vaccination have raised concern about the safety of YF vaccine, particularly among older vaccinees. We investigated the age-related reporting rates of adverse events following YF vaccination reported to the Australian Adverse Drug Reactions Advisory Committee for the period 1993 to 2002. The reporting rate of systemic adverse events leading to hospitalisation or death was signifi cantly higher among vaccinees aged ≥65 years [reporting rate ratio (RRR) 8.95, 95% confi dence interval (CI) 1.49–53.5] or ≥45 years (RRR 5.30, 95% CI 1.33–21.2) compared with younger YF vaccinees. The higher reporting rates among older vaccinees are similar to those identifi ed in the United States of America. The data highlight the importance of assessing the destination-specifi c risk, especially for older travellers to yellow fever endemic areas, and careful monitoring of those who are vaccinated
关键词：vaccination; yellow fever