摘要:John Hunter Hospital, a 600 bed tertiary referral centre, has an antimicrobial working party comprisingrepresentatives from pharmacy, microbiology and infectious diseases areas, which is responsible forthe development, implementation and evaluation of guidelines for the appropriate use of anti-microbials. Activities include the development and promotion of a restricted antimicrobial policy, andspecific guidelines for the management of pneumonia, and surgical prophylaxis and wound infection.These guidelines are available on the hospital intranet, in hard copies in all wards, and on laminatedcards (10 x 6.5 cm) attached to the hospital identification tag. Active promotion of the guidelines isundertaken at orientation and via a 2 week intensive period four times per year (corresponding withthe registrar rotation), weekly meetings and follow up of non-compliance courses directly with theattending medical officer. Education and feedback to specific groups is provided as required. Otherprojects include a campaign to encourage oral antibiotics where indicated. Regular drug utilisationevaluations are undertaken to measure outcomes, along with other indicators of antibiotic use suchas the prevalence of antimicrobial resistance. Appropriate prescribing of third generationcephalosporins has increased from 21 per cent to 52 per cent (p = 0.008) of courses betweenDecember 1999 and June 2001