文章基本信息

标题：Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline
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作者：Fiona E. Harrison ; Gene L. Bowman ; Maria Cristina Polidori 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2014
卷号：6
期号：4
页码：1752-1781
DOI：10.3390/nu6041752
语种：English
出版社：MDPI Publishing
摘要：This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive decline up to Alzheimer’s disease. Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration.
关键词：ascorbic acid; vitamin C; brain; cognitive function; alzheimer’s disease; dementia; aging; elderly; endothelial function; blood-brain barrier; SVCT (sodium-dependent vitamin C transporter)