文章基本信息

标题：Chemopreventive Potential of Flavonoids in Oral Squamous Cell Carcinoma in Human Studies
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作者：Marcello Iriti ; Elena Maria Varoni
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2013
卷号：5
期号：7
页码：2564-2576
DOI：10.3390/nu5072564
语种：English
出版社：MDPI Publishing
摘要：Evidence available from nutritional epidemiology has indicated an inverse association between regular consumption of fruits and vegetables and the risk of developing certain types of cancer. In turn, preclinical studies have attributed the health-promoting effects of plant foods to some groups of phytochemicals, by virtue of their many biological activities. In this survey, we briefly examine the chemopreventive potential of flavonoids and flavonoid-rich foods in human oral carcinogenesis. Despite the paucity of data from clinical trials and epidemiological studies, in comparison to in vitro/in vivo investigations, a high level of evidence has been reported for epigallocatechin gallate (EGCG) and anthocyanins. These flavonoids, abundant in green tea and black raspberries, respectively, represent promising chemopreventive agents in human oral cancer.
关键词：oral cancer; polyphenols; anthocyanins; tea; black raspberry; nanochemoprevention; nanoparticles; transmucosal oral delivery