文章基本信息

标题：Vitamin D and Immune Function
本地全文：下载
作者：Barbara Prietl ; Gerlies Treiber ; Thomas R. Pieber 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2013
卷号：5
期号：7
页码：2502-2521
DOI：10.3390/nu5072502
语种：English
出版社：MDPI Publishing
摘要：Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.
关键词：vitamin D; autoimmunity; immune cells; adaptive immunity; innate immunity; cholecalciferol; calcitriol; 25(OH)D