文章基本信息

标题：Vitamin E Isoforms as Modulators of Lung Inflammation
本地全文：下载
作者：Hiam Abdala-Valencia ; Sergejs Berdnikovs ; Joan M. Cook-Mills 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2013
卷号：5
期号：11
页码：4347-4363
DOI：10.3390/nu5114347
语种：English
出版社：MDPI Publishing
摘要：Asthma and allergic diseases are complex conditions caused by a combination of genetic and environmental factors. Clinical studies suggest a number of protective dietary factors for asthma, including vitamin E. However, studies of vitamin E in allergy commonly result in seemingly conflicting outcomes. Recent work indicates that allergic inflammation is inhibited by supplementation with the purified natural vitamin E isoform α-tocopherol but elevated by the isoform γ-tocopherol when administered at physiological tissue concentrations. In this review, we discuss opposing regulatory effects of α-tocopherol and γ-tocopherol on allergic lung inflammation in clinical trials and in animal studies. A better understanding of the differential regulation of inflammation by isoforms of vitamin E provides a basis towards the design of clinical studies and diets that would effectively modulate inflammatory pathways in lung disease.
关键词：tocopherols; lung disease; endothelial