文章基本信息

标题：Vitamin D — Effects on Skeletal and Extraskeletal Health and the Need for Supplementation
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作者：Matthias Wacker ; Michael F. Holick
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2013
卷号：5
期号：1
页码：111-148
DOI：10.3390/nu5010111
语种：English
出版社：MDPI Publishing
摘要：Vitamin D, the sunshine vitamin, has received a lot of attention recently as a result of a meteoric rise in the number of publications showing that vitamin D plays a crucial role in a plethora of physiological functions and associating vitamin D deficiency with many acute and chronic illnesses including disorders of calcium metabolism, autoimmune diseases, some cancers, type 2 diabetes mellitus, cardiovascular disease and infectious diseases. Vitamin D deficiency is now recognized as a global pandemic. The major cause for vitamin D deficiency is the lack of appreciation that sun exposure has been and continues to be the major source of vitamin D for children and adults of all ages. Vitamin D plays a crucial role in the development and maintenance of a healthy skeleton throughout life. There remains some controversy regarding what blood level of 25-hydroxyvitamin D should be attained for both bone health and reducing risk for vitamin D deficiency associated acute and chronic diseases and how much vitamin D should be supplemented.
关键词：vitamin D; 25-hydroxyvitamin D; vitamin D deficiency; osteoporosis; fractures; cancer; type 2 diabetes mellitus; cardiovascular diseases; autoimmune diseases; infectious diseases