文章基本信息

标题：Immunological Function of Sphingosine 1-Phosphate in the Intestine
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作者：Jun Kunisawa ; Hiroshi Kiyono
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2012
卷号：4
期号：3
页码：154-166
DOI：10.3390/nu4030154
语种：English
出版社：MDPI Publishing
摘要：It has been shown that dietary materials are involved in immune regulation in the intestine. Lipids mediate immune regulation through a complex metabolic network that produces many kinds of lipid mediators. Sphingosine-1-phosphate (S1P) is a lipid mediator that controls cell trafficking and activation. In this review, we focus on the immunological functions of S1P in the regulation of intestinal immune responses such as immunoglobulin A production and unique T cell trafficking, and its role in the development of intestinal immune diseases such as food allergies and intestinal inflammation, and also discuss the relationship between dietary materials and S1P metabolism.
关键词：intestinal immunity; lipid; IgA antibody; intraepithelial T lymphocytes; food allergy