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标题：Associations between Maternal Antioxidant Intakes in Pregnancy and Infant Allergic Outcomes
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作者：Christina E. West ; Janet Dunstan ; Suzi McCarthy 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2012
卷号：4
期号：11
页码：1747-1758
DOI：10.3390/nu4111747
语种：English
出版社：MDPI Publishing
摘要：Antioxidant intakes in pregnancy may influence fetal immune programming and the risk of allergic disease. We investigated associations between maternal intakes of β-carotene, vitamin C, vitamin E, copper and zinc, and infant allergic outcomes. Antioxidant intakes of pregnant women (n = 420) assessed prospectively by a food frequency questionnaire, were examined in relation to allergic outcomes at 1 year of age (n = 300). The main relationships with allergic outcomes were seen with dietary vitamin C and copper. Specifically, higher maternal dietary vitamin C intake was associated with a reduced risk of any diagnosed infant allergic disease and wheeze. After adjustment for potential confounders the relationship with wheeze remained statistically significant. There was also an inverse linear relationship between vitamin C and food allergy. Higher dietary copper intake was associated with reduced risk of eczema, wheeze and any allergic disease. The relationship with wheeze and any allergic disease remained statistically significant in multivariate analysis, and there was also an inverse linear relationship between copper and food allergy. However, these relationships were only seen for nutrients present in food. There were no relationships between β-carotene, vitamin E or zinc and any allergic outcomes. In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes.
关键词：allergy; allergic disease; antioxidant; childhood; copper; diet; dietary intake; eczema; pregnancy; vitamin C