文章基本信息

标题：Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?
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作者：Anderson P. Jones ; Meri K. Tulic ; Kristina Rueter 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2012
卷号：4
期号：1
页码：13-28
DOI：10.3390/nu4010013
语种：English
出版社：MDPI Publishing
摘要：A role for vitamin D in the regulation of immune function was first proposed after the identification of Vitamin D Receptors in lymphocytes. It has since been recognized that the active form of vitamin D, 1α,25(OH)2D3, has direct affects on naïve and activated helper T cells, regulatory T cells, activated B cells and dendritic cells. There is a growing body of literature linking vitamin D (serum 25(OH)D, oral intake and surrogate indicators such as latitude) to various immune-related conditions, including allergy, although the nature of this relationship is still unclear. This review explores the findings of epidemiological, clinical and laboratory research, and the potential role of vitamin D in promoting the inappropriate immune responses which underpin the rise in a broad range of immune diseases.
关键词：vitamin D; 25(OH)D; helper T cells; allergy; vitamin D receptor; immune system