文章基本信息

标题：Effect of Lactobacilli on Paracellular Permeability in the Gut
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作者：Siv Ahrne ; Marie-Louise Johansson Hagslatt
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2011
卷号：3
期号：1
页码：104-117
DOI：10.3390/nu3010104
语种：English
出版社：MDPI Publishing
摘要：Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the tight junctions. More precisely, short-term administration of L. plantarum WCSF1 to healthy volunteers increased the relocation of occludin and ZO-1 into the tight junction area between duodenal epithelial cells.
关键词：intestinal lactobacilli; probiotics; paracellular permeability; tight junctions