文章基本信息

标题：Is Excess Calcium Harmful to Health?
本地全文：下载
作者：Robin M. Daly ; Peter R. Ebeling
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2010
卷号：2
期号：5
页码：505-522
DOI：10.3390/nu2050505
语种：English
出版社：MDPI Publishing
摘要：Most current guidelines recommend that older adults and the elderly strive for a total calcium intake (diet and supplements) of 1,000 to 1,300 mg/day to prevent osteoporosis and fractures. Traditionally, calcium supplements have been considered safe, effective and well tolerated, but their safety has recently been questioned due to potential adverse effects on vascular disease which may increase mortality. For example, the findings from a meta-analysis of randomized controlled trials (currently published in abstract form only) revealed that the use of calcium supplements was associated with an ~30% increased risk of myocardial infarction. If high levels of calcium are harmful to health, this may alter current public health recommendations with regard to the use of calcium supplements for preventing osteoporosis. In this review, we provide an overview of the latest information from human observational and prospective studies, randomized controlled trials and meta-analyses related to the effects of calcium supplementation on vascular disease and related risk factors, including blood pressure, lipid and lipoprotein levels and vascular calcification.
关键词：calcium supplementation; cardiovascular disease; mortality; elderly