文章基本信息

标题：Assessment of Information to Substantiate a Health Claim on the Prevention of Prostate Cancer by Lignans
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作者：Niina M. Saarinen ; Juhani Tuominen ; Liisa Pylkkänen 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2010
卷号：2
期号：2
页码：99-115
DOI：10.3390/nu2020099
语种：English
出版社：MDPI Publishing
摘要：Lignans and their in vivo metabolites, especially enterolactone (ENL), have attracted substantial interest as potential chemopreventive agents for prostate cancer. Preclinical and clinical interventions performed with lignan-rich flaxseed that use surrogate biomarkers as endpoints suggest that lignans may attenuate prostate carcinogenesis in individuals with increased risk or with diagnosed cancer. No unequivocal prostate cancer risk reduction has been found for lignans in epidemiological studies, suggesting that lignan concentrations found in populations consuming a regular non-supplemented diet are not chemopreventive in prostate cancer. Presumably, the main obstacles in assessing the efficacy of food lignans is limited knowledge of the serum and tissue lignan concentrations required for the putative prevention. Further clinical studies performed with the purified compounds are required to substantiate a health claim.
关键词：lignan; phytoestrogen; diet; prostate cancer; health claim; surrogate biomarker