文章基本信息

标题：Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability
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作者：Jonathan D. Buckley ; Ross N. Butler ; Emma Southcott 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2009
卷号：1
期号：2
页码：224-234
DOI：10.3390/nu1020224
语种：English
出版社：MDPI Publishing
摘要：Endurance exercise training can increase intestinal permeability which may contribute to the development of gastrointestinal symptoms in some athletes. Bovine colostrum (BC) supplementation reduces intestinal permeability induced by non-steroidal anti-inflammatory drugs. This study aimed to determine whether BC could also reduce intestinal permeability induced by endurance exercise. Thirty healthy adult males (25.0 ± 4.7 yr; mean ± SD) completed eight weeks of running three times per week for 45 minutes at their lactate threshold while consuming 60 g/day of BC, whey protein (WP) or control (CON). Intestinal permeability was assessed at baseline and after eight weeks by measuring the ratio of urinary lactulose (L) and rhamnose (R) excretion. After eight weeks the L/R ratio increased significantly more in volunteers consuming BC (251 ± 140%) compared with WP (21 ± 35%, P < 0.05) and CON (−7 ± 13%, P < 0.02). The increase in intestinal permeability with BC may have been due to BC inducing greater leakiness of tight junctions between enterocytes or by increasing macromolecular transport as it does in neonatal gut. Further research should investigate the potential for BC to increase intestinal macromolecular transport in adults.
关键词：intestinal transport; exercise; gut permeability; lactulose; rhamnose