文章基本信息

标题：Dietary Supplementation with Conjugated Linoleic Acid Plus n-3 Polyunsaturated Fatty Acid Increases Food Intake and Brown Adipose Tissue in Rats
本地全文：下载
作者：Alan A. Sneddon ; D. Vernon Rayner ; Sharon E. Mitchell 等
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2009
卷号：1
期号：2
页码：178-196
DOI：10.3390/nu1020178
语种：English
出版社：MDPI Publishing
摘要：The effect of supplementation with 1% conjugated linoleic acid and 1% n-3 long chain polyunsaturated fatty acids (CLA/n-3) was assessed in rats. Food intake increased with no difference in body weights. White adipose tissue weights were reduced whereas brown adipose tissue and uncoupling protein-1 expression were increased. Plasma adiponectin, triglyceride and cholesterol levels were reduced while leptin, ghrelin and liver weight and lipid content were unchanged. Hypothalamic gene expression measurements revealed increased expression of orexigenic and decreased expression of anorexigenic signals. Thus, CLA/n-3 increases food intake without affecting body weight potentially through increasing BAT size and up-regulating UCP-1 in rats.
关键词：conjugated linoleic acid; n-3 long chain polyunsaturated fatty acid; white adipose tissue; brown adipose tissue; hypothalamus; brain