文章基本信息

标题：Dietary Calcium and Dairy Modulation of Oxidative Stress and Mortality in aP2-Agouti and Wild-type Mice
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作者：Antje Bruckbauer ; Michael B. Zemel
期刊名称：Nutrients
电子版ISSN：2072-6643
出版年度：2009
卷号：1
期号：1
页码：50-70
DOI：10.3390/nu1010050
语种：English
出版社：MDPI Publishing
摘要：Oxidative and inflammatory stress have been implicated as major contributors to the aging process. Dietary Ca reduced both factors in short-term interventions, while milk exerted a greater effect than supplemental Ca. In this work, we examined the effects of life-long supplemental and dairy calcium on lifespan and life-span related biomarkers in aP2-agouti transgenic (model of diet-induced obesity) and wild-type mice fed obesigenic diets until their death. These data demonstrate that dairy Ca exerts sustained effects resulting in attenuated adiposity, protection against age-related muscle loss and reduction of oxidative and inflammatory stress in both mouse strains. Although these effects did not alter maximum lifespan, they did suppress early mortality in wild-type mice, but not in aP2-agouti transgenic mice.
关键词：aging; lifespan; oxidative stress; inflammatory stress; dietary calcium; dairy