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标题：Graphene and Other Nanomaterial-Based Electrochemical Aptasensors
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作者：Frank J. Hernandez ; Veli Cengiz Ozalp
期刊名称：Biosensors
电子版ISSN：2079-6374
出版年度：2012
卷号：2
期号：1
页码：1-14
DOI：10.3390/bios2010001
语种：English
出版社：MDPI Publishing
摘要：Electrochemical aptasensors, which are based on the specificity of aptamer-target recognition, with electrochemical transduction for analytical purposes have received particular attention due to their high sensitivity and selectivity, simple instrumentation, as well as low production cost. Aptamers are functional nucleic acids with specific and high affinity to their targets, similar to antibodies. However, they are completely selected in vitro in contrast to antibodies. Due to their stability, easy chemical modifications and proneness to nanostructured device construction, aptamer-based sensors have been incorporated in a variety of applications including electrochemical sensing devices. In recent years, the performance of aptasensors has been augmented by incorporating novel nanomaterials in the preparation of better electrochemical sensors. In this review, we summarize the recent trends in the use of nanomaterials for developing electrochemical aptasensors.
关键词：aptamers; aptasensors; biosensors; electrochemistry; nanobiotechnology; graphene; carbon nanotubes