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  • 标题:Postprandial response of plasma IL-6 to isoenergetic meals rich in casein or potato singly and combined in obese women
  • 本地全文:下载
  • 作者:Patrick J. Manning ; Wayne H. F. Sutherland ; Sylvia A. de Jong
  • 期刊名称:Journal of Nutritional Science
  • 印刷版ISSN:2048-6790
  • 电子版ISSN:2048-6790
  • 出版年度:2013
  • 卷号:2
  • 页码:e30
  • DOI:10.1017/jns.2013.25
  • 语种:English
  • 出版社:Cambridge University Press
  • 摘要:

    Milk consumption decreases inflammatory stress in overweight and obese subjects. Casein is the major protein in milk and enhances the secretion of insulin that has anti-inflammatory activity. The aim of the present study was to compare the acute effect of meals rich in casein and carbohydrate and a combination of both nutrients on postprandial plasma concentrations of IL-6, a marker of inflammation, in obese women. A total of twenty-five obese women aged 38–68 years consumed isoenergetic meals rich in potato (POT) or casein (CA) or a combination of both these meals (POT + CA), in random order in a cross-over trial. After an overnight fast, blood samples were collected before and at 1 and 4 h after the meals and circulating concentrations of IL-6, glucose, insulin and NEFA were measured. Plasma IL-6 concentrations increased significantly (P < 0·001) during 4 h after the meals. The AUC of postprandial IL-6 concentrations was not significantly (P = 0·77) different among the meals. Postprandial serum insulin concentration AUC was significantly higher during the POT + CA meal compared with the POT meal (P = 0·001) and the CA meal (P < 0·05), which in turn was significantly higher than the POT meal (P < 0·05). These data show that while ingestion of CA alone or combined with POT acutely increases circulating insulin concentrations, it does not appreciably alter the postprandial increase in plasma IL-6 concentrations in obese women.

  • 关键词:IL-6; Obesity; Casein; Carbohydrate; Postprandial responses
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