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标题：SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems
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作者：Brendan N. Lilley ; Arjun Krishnaswamy ; Zhi Wang 等
期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2014
卷号：111
期号：3
页码：1138-1143
DOI：10.1073/pnas.1321990111
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：Axons develop in a series of steps, beginning with specification, outgrowth, and arborization, and terminating with formation and maturation of presynaptic specializations. We found previously that the SAD-A and SAD-B kinases are required for axon specification and arborization in subsets of mouse neurons. Here, we show that following these steps, SAD kinases become localized to synaptic sites and are required within presynaptic cells for structural and functional maturation of synapses in both peripheral and central nervous systems. Deleting SADs from sensory neurons can perturb either axonal arborization or nerve terminal maturation, depending on the stage of deletion. Thus, a single pair of kinases plays multiple, sequential roles in axonal differentiation.
关键词：neuromuscular junction ; sympathetic ganglion ; spinal cord ; Ia synapse ; Calyx of Held