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标题：Impact of different modifiable factors on hearing function in type 1 and type 2 diabetic subjects . A preliminary study
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作者：Mariusz Dąbrowski ; Grażyna Mielnik-Niedzielska ; Andrzej Nowakowski 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2013
卷号：20
期号：4
页码：773-778
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective: Hearing impairment in diabetic subjects is more prevalent than in the general population. Ageing, noise exposure and smoking are known as risk fac tors of hearing loss. The aim of this study was to assess whether other factors, such as HbA1c, blood pressure, serum lipids and BMI have an impact on hearing function among relatively young diabetic subjects. Materials and Methods: 58 patients, 31 with type 1 diabetes and 27 with type 2 diabetes, aged < 45 years, with diabetes duration < 10 years and without overt hearing impairment were included. In all subjec ts, vital signs, laboratory tests, pure-tone audiometry and trancient-evoked otoacoustic emissions (TEOAE) were evaluated. Results: Hearing impairment was revealed in 20 subjec ts. This group had a lower HDL-cholesterol level compared with normal hearing patients (44.2. mg/dl vs. 57.6. mg/dl, p=0.007). Absence of otoacoustic emissions was diagnosed in 16 subjects. These patients also had a lower HDL-cholesterol level compared with subjects with TEOAE present (45.4.mg/dl vs. 55.2.mg/dl, p=0.018). Hearing threshold was inversely correlated with HDL-cholesterol level, and positively correlated with triglycerides. Patients with HDL-cholesterol level ≥50.mg/dl had lower hearing threshold at frequencies 0.5–12 kHz, as well as higher TEOAE amplitude. Subjects with triglycerides above median had a higher hearing threshold at frequencies 0.5–12 kHz, as well as lower TEOAE amplitude. Patients with elevated BMI (≥25.kg/m2) had a higher hearing threshold at frequencies 2–12 kHz, as well as lower TEOAE amplitude. Conclusions: Hearing impairment is frequent among relatively young diabetic subjects. The preseted study reveals that factors like HDL-cholesterol, triglycerides, and BMI may affect hearing func tion in this group
关键词：diabetes mellitus; hearing impairment; pure-tone audiometry; otoacoustic emissions; risk factors