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标题：In vitro evaluation of the effect of tobacco smoke on rat cornea function
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作者：Ewa Marzec ; Jan Olszewski ; Jacek Piątek 等
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2012
卷号：19
期号：4
页码：677-679
出版社：Institute of Agricultural Medicine in Lublin
摘要：The in uence of tobacco smoke on the dielectric properties of rat cornea were measured in vitro over the frequency range of the electric eld of 500Hz–100kHz and in temperatures of the air from 25 to 150 °C. The temperature dependencies of the loss tangent for both healthy and smoky cornea represent the relation between the energy lost and the energy stored in the epithelium-stromal-endothelium systems of the cornea. The di erences between the healthy and the smoky cornea concerned the temperature ranges in which there appeared the decomposition of loosely-bound water and β-relaxation associated with polar side- chains relaxations on protein molecules of this tissue. The e ect of smoke is manifested as a shift of the loss tangent peaks of these two processes towards higher temperatures, when compared with the control. The results are interpreted as caused by the tox ic compounds of the tobacco smoke leading to higher ion transport in the nonhomogeneous structure of the cornea when compared to that of the control tissue. The activation energy of conductivity were similar for the healthy and smoky cornea as a consequence of the braking of hydrogen and Van der Waals bonds between loosely bound water, and the proteins of channels in the epithelium and endothelium. Recognition of the e ect of frequenc y and temperature on the dielectric behaviour of the smoky cornea may be of interest for disease charac terization of this tissue.
关键词：cornea; tobacco smoke; loss tangent; water; tear lm; activation energy